Nucleotide Analogues

Like the nucleoside analogues such as AZT and ddI, nucleotide analogues inhibit reverse transcriptase. However, they are active in their native form, unlike nucleosides that only work in cells that have the machinery to activate the drug by a process called phosphorylation. This means that the nucleotide analogues may be active against HIV in a wider variety of infected cells.

• Viread (tenofovir)

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