Definition: Progressive multifocal leukoencephalopathy (PML) is a rapidly debilitating opportunistic infection caused by the JC virus that infects brain tissue and causes damage to the brain and spinal cord. Symptoms vary from patient to patient but include loss of muscle control, paralysis, blindness, problems with speech, and an altered mental state. PML can lead to coma and death. In most cases, HAART regimens consisting of medications known to cross the blood-brain barrier are used to treat PML.
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Also Known As: PML
