Definition: A degenerative neurological condition attributed to HIV infection, characterized by:
- loss of coordination
- mood swings or changes
- loss of inhibitions
- mental status changes
- changes in personality
- widespread cognitive dysfunctions.
It is the most common central nervous system complication of HIV infection. Characteristically, it manifests itself after the patient develops major opportunistic infections or AIDS-related cancers. However, patients can also have this syndrome before these major systemic complications occur.
