Definition: A group of structurally diverse compounds that bind to the catalytic site of HIV-1's reverse transcriptase. They are quite specific; unlike the nucleoside reverse transcriptase inhibitors, the NNRTIs have no activity against HIV-2. As noncompetitive inhibitors of reverse transcriptase, their antiviral activity is additive or synergistic with most other antiretroviral agents. However drug-drug interactions may dictate dosage adjustments with protease inhibitors.
For more information on NNRTIs or other HIV medications see our medication fact sheets.
Also Known As: "NNRTI"

