Aptivus (tipranavir)

_{Aptivus must be taken with Norvir 200mg twice daily to be effective}

• nausea / vomiting / diarrhea
• rash
• headache
• fatique
• yellowing of the skin (jaundice) that could be a sign of liver toxicity

Special Warning! - In patients taking Norvir boosted Aptivus, there is a risk of rash and liver toxicity. Aptivus should be discontinued if liver function studies become abnormally high. If you develop yellowing of the skin or the whites of the eyes, call your doctor immediately.

• sulfa allergies are possible with Aptivus. Use caution if you have a sulfa (Bactrim) allergy.
• St. John's Wort can decrease the effectiveness of Aptivus
• Aptivus can decrease the effectiveness of birth control pills or patches. A second source of birth control must be used when taking Aptivus.
• antiarrythmic meds, cholesterol lowering meds, and herbal remedies can have serious interactions with Aptivus. Notify your doctor of all your medicines prior to starting Aptivus.

_{Source - Waknine, Y.; FDA Safety Changes: Aptivus; Medscape Medical News; 2008.}