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List of Approved Antiretroviral Drugs - HIV/AIDS

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Updated June 19, 2014

Written or reviewed by a board-certified physician. See About.com's Medical Review Board.

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Antiretroviral drugs are organized into five classes based on the stage of the HIV life cycle they are known to inhibit. Today, there are 27 individual agents (known as "drug molecules") and seven fixed dosed combination (FDC) drugs comprised of two or more of different molecules. Three of the FDCs can, in fact, be used as a single-pill, once-daily therapy, ensuring greater treatment adherence and ease of use.

Drug Class Brand Name Generic Name Adult Dosing Dietary Notes
Entry Inhibitors Fuzeon enfuvirtide, T-20 90mg (1 mL) injected twice
daily
None
  Selzentry,
Celsentri
maraviroc One 150mg tablet twice
daily, one 300mg tablet
twice daily, or two 300mg
tablets twice daily,
depending on drug regimen
None
Integrase Inhibitors Isentress ratelgravir One 400mg tablet taken
twice daily
Taken with or
without food
  Tivicay dolutegravir One 50mg tablet daily for
untreated patients; one

50mg tablet twice daily for
treatment-experienced
patients with resistance to

Isentress
Taken with or
without food
Nucleoside/Nucleotide
Reverse Transcriptase
Inhibitors
(NRTIs/NtRTIs)
Emtriva emtricitabine One 100mg tablet taken
once daily, or one 150mg
tablet taken twice daily
Taken with or
without food
  Epivir lamivudine One 300mg tablet taken
once daily, or one 150mg
tablet taken twice daily
Taken with or
without food
  Retrovir AZT, zidovudine One 300mg tablet taken
twice daily
Food may
ease stomach
discomfort
  Videx EC didanosine, ddI One 400mg capsule
taken once daily; or one
200mg capsule taken
once daily for patients
under 133 lbs (60kg)
Taken on
empty stomach
  Viread tenofovir One 300mg tablet taken
once daily
Taken with or
without food
  Zerit stavudine One 40mg capsule taken
12 hourly for patients
133 lb (60kg) and over; or
one 30mg capsule taken
12 hourly for patients
less than 133 lbs (60kg)
Taken with or
without food
  Ziagen abacavir Two 300mg tablets taken
once daily, or one 300mg
tablet taken twice daily
Taken with or
without food
Non-Nucleoside
Reverse Transcriptase
Inhibitors (NNRTIs)
Edurant rilpivirine One 25mg tablet taken
once daily
Taken with a
meal
  Intelence etravirine One 200mg tablet taken
twice daily
Taken with a
meal
  Rescriptor delavirdine Two 200mg tablets taken
three times daily
Taken with or
without food
  Sustiva,
Stocrin
efavirenz One 600mg tablet taken
once daily
Recommend
empty stomach
  Viramune XR nevirapine Induction dose of one
200mg Viramune tablet
daily for 14 days, then one
100mg Viramune XR
tablet daily
Taken with or
without food
Protease Inhibitors
(PIs)
Aptivus tipranavir Two 250mg capsules
taken with 200mg Norvir
twice daily
Best taken
with a meal
  Crixivan indinavir Two 400mg capsules
taken with either 100mg
or 200mg Norvir twice
daily (preferred), or
two 400mg capsules
taken every 8 hours
With Norvir,
take with or
without food;
without Norvir,
take on empty
stomach
  Invirase saquinavir Two 500mg tablets taken
with 100mg Norvir twice
daily
Best taken
with food or
within 2 hours
of eating
  Kaletra,
Aluvia
200 mg lopinavir
+ 50mg Norvir
(Note - lopinavir
is only available
as part of
Kaletra/Aluvia)
Two tablets twice daily;
four tablets once daily is
acceptable for untreated
patients or patients with
less than 3 mutations
associated with lopinavir
resistance
Taken with or
without food
  Lexiva,
Telzir
fosamprenavir Two 700mg tablets taken
twice daily; or two 700mg
tablets taken with 100mg
100mg Norvir once daily;
or one 700mg tablet
taken with 100mg Norvir
twice daily for patients
with previous PI failure
Taken with or
without food
  Norvir ritonavir Norvir is almost
exclusively used to
"boost" (or sustain) levels
of other PIs in the blood
N/A
  Prezista darunavir One 800mg tablet (or two
400mg tablets) taken
with 100mg Norvir once

daily; or one 600mg
tablet taken with 100mg
Norvir twice daily for
patients with known
levels of Prezista-
associated resistance
Taken with
food
  Reyataz atazanavir Two 200mg capsules
taken once daily, or one
300mg (or two 150mg)
capsules taken with
100mg Norvir once daily
Taken with
light meal
  Viracept nelfinavir Two 625mg tablets
taken twice daily, or five
250mg tablets taken
twice daily, or three
250mg tablets taken
three times daily
Taken with
a meal or
light snack
Fixed Dose
Combination
(FDC) Drugs
Combivir 300mg Retrovir
+ 150mg Epivir
One tablet taken twice
daily
Food may
ease stomach
discomfort
  Epzicom,
Kivexa
600mg Ziagen
+ 300mg Epivir
One tablet taken once
daily
Taken with or
without food
  Truvada 300mg Viread
+ 200mg Emtriva
One tablet taken once
daily
Taken with or
without food
All-in-One Fixed
Dose Combination
(FDC) Drugs
Atripla 600mg Sustiva
+ 300mg Viread
+ 200mg Emtriva
One tablet taken once
daily; no other
antiretroviral agent
needed
Best on
empty stomach
  Complera 25mg Edurant
+ 300mg Viread
+ 200mg Emtriva
One tablet taken once
daily; no other
antiretroviral agent
needed
Best taken
with food
  Stribild 150mg elvitegravir
+ 150mg cobicistat
+ 300mg Viread
+ 200mg Emtriva
(Note - elvitegravir
and cobicistat are
only available as
part of Stribild)
One tablet taken once
daily; no other
antiretroviral agent
needed
Best taken
with food
  Trizivir 300mg Ziagen
+ 300mg Retrovir
+ 150mg Epivir
One tablet taken twice
daily; can be prescribed
alone or in combination
with other antiretroviral
agents
Best taken
with food
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